98% up by HPLC Alarelin Acetate 79561-22-1

Category:Bio Products > Protein/Antigen/Polypeptide > Other Protein
Product Name:98% up by HPLC Alarelin Acetate 79561-22-1
CAS No.:79561-22-1
Standard:In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Xiamen Fujian

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Monthly Production Capacity: 10ton/year

    Packaging Information: 25kg/drum; 5kg/bag, 1kg/bag

  • Delivery Lead Time: 7 days after payment

    Sample Provided: yes

    Payment Terms: L/L

     

    Product Information

     

    Product name

    Alarelin Acetate 79561-22-1

    CAS No.

    79561-22-1

    Molecular Formula

    C56H78N16O12

    Molecular Weight

    1167.34

    Quality Standard

    98% up by HPLC

    Appearance

    White powder

    Sequence

    Glp-His-Trp-Ser-Tyr-DAla-Leu-Arg-Pro-NHEt

     

    COA of Alarelin Acetate

     

      Items

    Specifications

    Results

    Appearance

    White or off-white powder

    White powder

    Solubility

    Sparingly soluble in MeOH, soluble in water and 1% acetate acid

    Sparingly soluble in MeOH, soluble in water and 1% acetate acid

    HPLC

    The principal peak in the chromatogram obtained with the test solution is similar in retention time to principal peak in the chromatogram obtained with the reference solution.

    Conforms

    Amino acid analysis

     

     Arg

     0.9-1.1

     1.0

     Ala

     0.9-1.1

     1.0

     His

     0.9-1.1

     1.0

     Leu

     0.9-1.1

     0.9

     Pro

     0.8-1.0

     1.0

     Tyr

     0.9-1.1

     1.0

     Glu

     0.9-1.1

     1.0

     Ser

     0.7-1.0

     0.7

     

     No more than the traces of the other amino acids are present.

    MS

    1167.3±1.0

    1167.4

    Related Substances

    Unspecified impurity for each impurity: NMT1.0%

    0.51%(single largest impurity)

    Purity

    NLT 98.0%

    99.26%

    Acetic acid

    NMT12.0%

    8.6%

    Water

    NMT7.0%

    4.3%

    Specific Optical Rotation

    -46.0 °to -56.0°(anhydrous and acetic acid free subtance)

    -48.0 °

    Bacterial endotoxins

    Less than 70IU/mg

    Conforms

    Assay

    97.0%-103.0% (anhydrous and acetic acid free subtance)

    99.4%

    Residual solvent

     

     Methanol

     NMT 3000ppm

    Conforms

     Acetonitrile

     NMT 410ppm

    Conforms

     Triethylamine

     NMT 320ppm

    Conforms

    Conclusion

    Meet the specification

     

    Usage

     

    Function of Alarelin Acetate

     

    Alarelin is a nonapeptide analogue of synthetic gonadotropin-releasing hormone (GnRH), and its efficacy is 15 times that of the parent. In the early stage of medication, it can stimulate the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), causing a temporary increase in ovarian-derived steroid hormones; repeated medication can inhibit the release of LH and FSH from the pituitary, and reduce the level of estradiol in the blood. To achieve the effect of drug ovariectomy, at the same time it has a regulatory effect on the expression of the related oncogenes ras, neu, and myc of endometrial cancer. Clinically, it is mainly used to promote ovulation, treat infertility caused by abnormal ovarian function, endometriosis and uterine fibroids, and improve pregnancy rate.

     

    Pharmacological action: This product is a nonapeptide analogue of synthetic gonadotropin releasing hormone (GnRH), which can stimulate the pituitary to release luteinizing hormone (LH) and follicle stimulating hormone (FSH) at the initial stage of treatment, causing transient ovarian-derived steroid hormones Increased; Repeated medication can inhibit the release of LH and FSH from the pituitary gland, reduce the level of estradiol in the blood, and achieve the effect of drug ovariectomy. This inhibitory effect can be used to treat hormone-dependent diseases such as endometriosis. The mechanism of action is to detect the expression of key intermediary proteins Smad2/3 and Smad7 in the TGF-β/smads signal transduction pathway in endometrial cancer transplanted tumor tissue, indicating that the TGF-β1/smads signal transduction pathway may be endometrial An important pathway in the pathogenesis of cancer. Alarelin may inhibit the occurrence and development of endometrial cancer by up-regulating Smad2/3 and down-regulating the expression of Smad7 protein. Pharmacokinetics: This product is rapidly absorbed after intramuscular injection in rats. The blood concentration reaches its peak in about 20 minutes, and the decrease in blood concentration is in line with the two-compartment model. When intramuscularly administered, t1/2α is about 0.2h, and t1/2β is about 1.8h. In intravenous administration, t1/2α is 0.08h, and t1/2β is about 1.2h. Its bioavailability can reach about 80%. The binding rate to plasma protein is 27% to 35%. The tissue distribution is by gonads and pituitary. The drug can be secreted from bile, completely metabolized and decomposed in the body within 24 hours, and all are excreted in urine and feces, of which 80% is in urine discharge.

     

    Application: Clinically, it is mainly used to promote ovulation, treat infertility caused by abnormal ovarian function, endometriosis and uterine fibroids, and improve pregnancy rate.

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