99% up by HPLC Donepezil 120014-06-4

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:99% up by HPLC Donepezil 120014-06-4
CAS No.:120014-06-4
Standard:USP, BP, EP, JP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Xiamen, Fujian

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East

  • Monthly Production Capacity: 1000kg

    Packaging Information: 25kg/drum 1kg/bottle

  • Delivery Lead Time: 7 days after payment

    Sample Provided: yes

    Payment Terms: L/L

     

    Product Information

     

    Product name

    Donepezil

    CAS No.

    120014-06-4

    Molecular Formula

    C24H29NO3

    Molecular Weight

    379.49

    Quality Standard

    99% up by HPLC

    Appearance

    White powder

     

    COA of Donepezil

     

    ITEMS

    SPECIFICATIONS

    RESULTS

    APPEARANCE

    WHITE OR ALMOST WHITE CRYSTALLINE POWDER

    CONFORMS

    SOLUBILITY

    TO MATCH WORKING STANDARD

    CONFORMS

    IDENTIFICATION

    1)     BY UV ABSORPTION,TO MATCH WORKING STANDARD

    2)     BY IR ABSORPTION,TO MATCH WORKING STANDARD

     

     

    CONFORMS

     

    CONFORMS

    MELTING POINT

    86-90℃

    87.5-88.5℃

    RELATED SUBSTANCE

    TOTAL

    ≤1.0%

    0.14%

    SINGLE IMPURITY (UNKNOWN)

    ≤0.80%

    <0.8%

    LOSS ON DRYING

    ≤1.0%

    0.3%

    RESIDUE ON IGNITION

    ≤0.10%

    0.02%

    HEAVY METAL

    ≤10 PPM

    <10 PPM

    ASSAY

    ≥99.0%

    99.87%

    CONCLUSION

    CONFORMS TO THE ENTERPRISE STANDARD

     

    Usage

     

    Function of Donepezil
     

    Donepezil is a potent, reversible, specific and noncompetitive acetylcholinesterase (AChE) inhibitor for the treatment of mild to moderate dementia.

     

    In vitro studies:

    Donepezil has a reversible and non-competitive inhibitory effect on AChE. It is 500-1000-fold more selective for AChE than for BuChE. Short- and long-term drug exposure to human SH-SY5Y neuroblastoma cells induces a concentration-dependent inhibition of cell proliferation independent of muscarinic or nicotinic receptor blockade and apoptosis. Donepezil reduces the number of cells in the S-G2/M phase of the cell cycle, increases the number in the G0/G1 phase, and reduces the expression of two cyclins in the G1/S and G2/M transitions: cyclinE and cyclinB. At the same time, it also increased the expression of the cell cycle repressor p21. In addition, donepezil increases action potential-dependent dopamine release and modulates nicotinic receptors in substantia nigra dopaminergic neurons.

    In vivo studies:

    Donepezil absorbs Chemicalbook slowly from the gastrointestinal tract in vivo, with a terminal half-life of 50-70 hours in young volunteers and more than 100 hours in elderly. After extensive hepatic metabolism, the parent compound is 93% bound to plasma proteins. Donepezil is metabolized in the liver by the cytochrome P450 system (CYP1A2-, CYP2D6-, CYP3A4-related enzymes). In animals, donepezil was unchanged in the brain and no metabolites were found in neural tissue. In plasma, urine and bile, most donepezil metabolites are O-glucuronides. After oral ingestion, peak plasma concentrations are reached within 3-5 hours, and its absorption is not affected by food. Donepezil has linear pharmacokinetics in the concentration range of 1-10 mg/day. 96% of circulating donepezil is protein bound.

     

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