99% up by HPLC Nonapeptide-1

Category:Bio Products > Protein/Antigen/Polypeptide > Other Protein
Product Name:99% up by HPLC Nonapeptide-1
CAS No.:158563-45-2
Standard:In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

Basic Info
  • Grade: Cosmetic Grade

    Factory Location: Xiamen Fujian

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Monthly Production Capacity: 10ton/year

    Packaging Information: 25kg/drum; 5kg/bag, 1kg/bag

  • Delivery Lead Time: 7 days after payment

    Sample Provided: yes

    Payment Terms: L/L

     

    Product Information

     

    Product name

    Nonapeptide-1

    CAS No.

    158563-45-2

    Molecular Formula

    C61H87N15O9S

    Molecular Weight

    1206.50

    Quality Standard

    99% up, Cosmetic Grade/Medicine Grade

    Appearance

    White powder

     

    COA of Nonapeptide-1

     

    TEST

    SPECIFICATION

    RESULTS

    Appearance

    White  powder

    Complies

    Identification

    IR

    Complies

     

    HPLC

    Complies 

    Heavy metal

    ≤10ppm

    5ppm

    Pb

    ≤3ppm

    1.5ppm

    Hg

    ≤0.1ppm

    0.05ppm

    Cd

    ≤1ppm

    0.2ppm

    Loss on drying

    ≤0.5%

    0.12

    Residue on lgnition

    ≤0.1%

    0.03

    Single impurity

    ≤0.5%

    0.12

    Total impurity

    ≤1.0%

    0.29

    Total bacteria

    ≤1000cfu/g

    <1000

    Yeast and Mould

    ≤100 cfu/g

    <000

    E.coli/25g

    Absent

    Absent

    Salmonella/25g

    Absent

    Absent

    Assay

    ≥99.0%

    99.4%

    Conclusion

    Conforms with USP/EP standards

     

    Usage

     

    Function of Nonapeptide-1

    Nonapeptide-1, also called Melanostatine™ 5, is a propriety peptide that was originally developed for its antimicrobial activities. Animal research has revealed, however, that nonapeptide-1 can inhibit the synthesis of melanin, which makes it of interest for treating certain skin conditions. Animal models suggest that nonapeptide-1 can reduce synthesis of melanin and help decrease skin pigmentation to a substantial degree.

      Nonapeptide-1 was first isolated from the yeast Streptomyces clavifer, but is now produced synthetically through recombinant genetic technology. It was first developed for its antimicrobial activities, but has since been found to be a strong inhibitor of melanin formation laboratory studies of yeast and melanoma (skin cancer) cells . Nonapeptide-1 consists of the amino acids arginine-lysine-methionine-phenylalanine-proline-tryptophan-valine.

     

      Research in fungi indicates that nonapeptide-1, at a concentration of 200 ug/mL, is capable of fully inhibiting the synthesis of melanin2. Fungi are used in this particular research because they more closely approximate conditions in human cells, but require fewer resources than animal models. Research in animal models indicates that nonapeptide-1 may effectively reduce pigmentation, after just one application, for up to 28 days at a timev[5]. At 100 micromolar concentration, nonapeptide-1 can inhibit 25-35% of tyrosinase activity in animal models and can reduce the melanin content of melanocytes by 27-43%.

      Nonapeptide-1 is of primary research interest for its ability to reduce hyperpigmentation by inhibiting the action of tyrosinase in melanin-producing cells. The ability to regulate melanin production has potential application in a number of conditions, including photodamage of the skin.

    Research also suggests that nonapeptide-1 may play a role in the central nervous system where it may act on both dopaminergic receptors and opioid receptors to modify pain signaling as well as behavior. Studies in mice support the idea that nonapeptide-1 may have central actions that affect behavior and pain.

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