Factory Supply 99% Synthetic Liraglutide Powder Peptide API CAS NO 204656-20-2

Factory Supply 99% Synthetic Liraglutide Powder Peptide API CAS NO 204656-20-2 

Introduction:

Liraglutide is a long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis.

Liraglutide is a recombinant DNA produced polypeptide analogue of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents. There have been no published reports of hepatotoxicity attributed to liraglutide therapy.

Liraglutide is a lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It has a role as a glucagon-like peptide-1 receptor agonist and a neuroprotective agent. It is a lipopeptide and a polypeptide.

Fuction &Application:

Liraglutide has the following pharmacological effects:
Protective effect on islet β cells
The effect of reducing body mass
Cardiovascular effects of liraglutide
Protective effect on the liver
Therapeutic effect on Alzheimer's disease (AD)

As a novel long-acting glP-1 analogue, liraglutide has 97% sequence homology with human GLP-1, which can bind and activate the GLP-1 receptor. Glp-1 receptor is the target of natural GLP-1, an endogenous intestinal Chemicalbook insulin stimulating hormone, which promotes the proliferation and differentiation of islet β cells, and significantly protects and improves the function of islet β cells. At the same time, liraglutide is simple and convenient to use, can provide 24h blood glucose control once a day, and the risk of hypoglycemia is small, and is expected to become a new drug for the treatment of type 2 diabetes.

                                 Certificate of Analysis

Storage:In an air tight container,protected from light at temperature2-8℃. Conclusion:the product complies with enterprise standard.

Not for human use without further processing.

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