palovarotene

Name: palovarotene
Availability: palovarotene-368786.html

Category:Intermediates > Pharmaceutical Intermediates
Product Name:palovarotene
CAS No.:410528-02-8
Standard:ChP, USP, BP, EP, JP, In-house Standards, IP, Ph. Int
Price(USD):Negotiable
Company:Jiangsu Magic Biotechnology Co., Ltd

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Basic Info

Grade: Pharmaceutical Grade

Factory Location: No.016, Fengwang Road, Wanggou Town, Feng County, Xuzhou City, Jiangsu Province

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Monthly Production Capacity: 100g

Contract Manufacturing: CRO,CMO
Delivery Lead Time: 1

Sample Provided: yes

Payment Terms: L/C

体内研究Palovarotenesuppressespost-traumaticchondrogenesisandosteogenesisandmitigatedtrauma-inducedectopicboneformation.Palovaroteneinhibitssubcutaneousandintramuscularheterotopicossification(HO)inmice.Palovaroteneisgivenorallyfor14daysat1mg/kg/daystartingonpost-operativeday(POD)1orPOD-5,andHOamount,wounddehiscenceandrelatedprocessesaremonitoredforupto84dayspostinjury.Comparedtovehicle-controlanimals,PalovarotenesignificantlydecreasesHOby50to60%regardlesChemicalbooksofwhenthetreatmentstartedandifinfectionispresent.Startingfromday1ofinjury,halfoftheAcvr1cR206H/+micearetreatedwithPalovarotenebydailygavagefor14daysandtheotherhalfreceivedvehicleascontrol.AnalysisbymCTand3Dimagereconstructionatday14showsthatlargeHOtissuemasseshaveformedinthetargetedlegofAcvr1cR206H/+mutantmicereceivingvehicle,butHOformationisgreatlydiminishedinPalovarotene-treatedcompanionsbymorethan80%basedonbonevolume/totalvolumequan

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